If you are not putting a blower on it or a lot of nitrous, I don't see a huge problem with the 2-bolt mains. I would recommend ARP main studs to help on the stability.
Years ago, I ran a 454 2-bolt main for several seasons. I ran a best of 9.53 @ 142 and shifted at 7000 in my Monte and it weighed about 2700lbs with me in it. So, it was putting about 575 to the ground and close to 650 at the flywheel. It did have the ARP main studs, GM cast crank, 3/8" dot rods (ARP rod bolts), TRW forged 11:1 closed chamber pistons, rectangular port closed chamber heads (ported 2.25" 1.88"), Crane .707/.707 roller, and tunnel ram with dual 750 dp's.
Bill M